2 Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Utrecht, Netherlands. 2009    The Queen Wilhelmina Dutch Cancer Society Award, Amsterdam 2011    The Ernst Jung Medical Award, Germany 2 Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Utrecht, Netherlands. Since 2008, the Hubrecht is affiliated with the UMC Utrecht. Hubrecht Organoid Technology or HUB was founded around Organoid Technology. These cells represent the epithelial stem cells of the small intestine and colon (23), the hair follicle (24), the stomach (28) and -probably- all other epithelial stem cell types of the mammalian body. Hubrecht Organoid Technology (HUB) was founded by the Hubrecht Institute, the University Medical Center Utrecht, and the Royal Netherlands Academy of Arts and Sciences (KNAW). Network. Independent work by the Feng Cong lab has first shown that R-spondin, when bound to Lgr5, captures and inactivates RNF43/ZNRF3. During the last five years, the Hubrecht Institute has been very successful in attracting young talented group leaders who started a tenure track at our institute. 2018 – present  Member of the Scientific Advisory Board of Merus, Utrecht Hans Clevers is both group leader at the Hubrecht Institute and scientific director of the PMC, ensuring a steady relationship. Cell 161: 933-945 (2015), 49)           Drost, J., van Jaarsveld, R.H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A.,Sachs, N., Overmeer, R.M., Offerhaus, G.J., Begthel, H. Korving, J., van de Wetering, M., Schwank, G. Logtenberg, M., Cuppen, E., Snippert, H.J., Medema, J.P., Kops, G. J. P. L., Clevers, H. Sequential cancer mutations in cultured human intestinal stem cells. 2020 – present  Chair of the Scientific Advisory Board of Xilis, at Duke University (NC), Uppsalalaan 8 2012    Knight in the Order of the Netherlands’ Lion Research groups. and Clevers, H. Intestinal Crypt Homeostasis results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells. 2012    Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize, Paris Researchers from the UMC Utrecht work alongside researchers from the Hubrecht Institute in this new building. 2012               Member of the Royal Netherlands Society of Sciences and Humanities Hubrecht Institute. This is reflected by our broad introduction program, yearly evaluation meetings and regular drinks and outings to improve integration, collaboration and relaxation. Science 307: 1904-1909 (2005), 19)           Reya, T., Clevers, H., Wnt signalling in stem cells and cancer. Nature Genetics 19: 379 383 (1998), 9)              Roose, J., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., van de Wetering, M., Destree, O., and Clevers, H. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Two other Wnt target genes, RNF43 and ZNRF3, encode stem cell-specific E3 ligases that downregulate Wnt receptors. 11 Oncode Institute, Hubrecht Institute-KNAW and UMC Utrecht, Utrecht, The Netherlands [email protected] The Hubrecht Institute strongly supports open access of all scientific publications. Lgr5 crypt stem cells behave in unanticipated ways: Against common belief, they divide constantly. Review. 2015                     Pezcoller Foundation – AACR International Award for Cancer Research, Italy 2015 – present  Member of the Scientific Advisory Board of the Institute of Molecular Pathology, Vienna Nature 556, 437-462 (2018). Science  358: 234-238 (2017). 2015    ISSCR-McEwen Award for Innovation This research leads to innovation in treatment of cancer, diabetes and cardiovascular diseases among others. Hans Clevers (Hubrecht Institute) states: "These organoids contain the cells of the human intestinal lining, making them a compelling model to investigate infection by SARS-CoV-2." Cell 127 (3), 469-480, 2006. Repaired stem cells were clonally expanded into mini-guts and shown -in a swelling assay- to contain a functional CFTR channel (43). Title. And Clevers, H. Schilham, M., Oosterwegel, M., Moerer, P., Jing Ya, de Boer, P., van de Wetering, M., Verbeek, S., S., Lamers, W., Kruisbeek, A., Cumano, A., and Clevers, H . On average, one group leader annually moves on to a new position outside the Institute. After completing his postdoctoral research between 1986 and 1989 at the Dana-Farber Cancer Institute at Harvard University, Clevers established his own laboratory for genetic research at Utrecht University. 2016    The Academy Professor Prize of the Royal Netherlands Academy Royal Netherlands Academy of Arts and Sciences (KNAW), Princess Máxima Center for pediatric oncology (PMC), European Molecular Biology Laboratory (EMBL), Celebrating 100 years of Developmental Biology at the Hubrecht Institute, Hubrecht Institute Centennial – From embryos to stem cells, On the shoulders of Hubrecht: From embryos to stem cells. Clevers was the first to identify living stem cells in the intestine and is one of the world's leading researchers on adult stem cells, their role in cancer and their potential for regenerative therapy. 2002 – present  Principal Investigator of a research group of ~40 scientists at Hubrecht Institute, Utrecht Cell 143:134-44 (2010), 33)           de Lau, W., Barker, N., Low, T.Y., Koo, B.K., Li, V.S., Teunissen, H., Kujala, P., Haegebarth, A., Peters, P.J., van de Wetering, M., Stange, D.E., van Es, J., Guardavaccaro, D., Schasfoort, R.B., Mohri, Y., Nishimori, K., Mohammed, S., Heck, A.J., Clevers, H. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. The Hubrecht is a highly dynamic, diverse and young institute where the average age of the researchers is around 30 and more than 30 different nationalities are represented. Science 340: 1190-1194 (2013), 41)           Clevers, H. The intestinal crypt, a prototype stem cell compartment. About Us. Prof. Dr. Nynke Dekker, Kavli Institute of Nanoscience, Delft Cell 151: 1595-1607 (2012), 39)           Huch, M., Dorrell, C., Boj, S.F., van Es, J.H., van de Wetering, M., Li, V.S.W., Hamer, K., Sasaki, N., Finegold, M.J., Haft, A., Grompe, M., Clevers, H. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. In the 1960’s, the Hubrecht Laboratory moved to a new building in the Uithof of Utrecht (nowadays called Utrecht Science Park the Uithof). Utrecht Life Sciences is a platform that supports collaboration and innovation. The Hubrecht Institute is one of the fifteen outstanding national research institutes of the Royal Netherlands Academy of Arts and Sciences (KNAW). Marie-José Goumans. In the absence of Wnt signaling, we found that Tcf factors associate with proteins of the Groucho family of transcriptional repressors to repress target gene transcription (9). Hans Clevers is both group leader at the Hubrecht Institute and scientific director of the PMC, ensuring a steady relationship. Researchers from the group of Hans Clevers at the Hubrecht Institute have modeled the development and progression of high-grade serous ovarian cancer in mini-versions of the female reproductive organs of the mouse. ); a.vanoudenaarden{at}hubrecht.eu (A.v.O.) Review Cell 111: 241-250 (2002), 14)           Batlle, E., Henderson, J.T., Beghtel, H., van den Born, M., Sancho, E., Huls, G., Meeldijk, J., Robertson, J., van de Wetering, M., Pawson, T., Clevers, H. Beta- catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. The Wnt target gene encoding the transcription factor Achaete scute-like 2 controls the fate of the intestinal stem cell (26). A variety of biological processes are being studied, mainly concerning embryonic development and development and homeostasis of organs. Nature 494: 247-250 (2013), 40)           Sato, T., Clevers, H.. [email protected] 2017               Member of the Orden Pour le Mérite für Wissenschaften und Künste, Germany [email protected] 2016    Swammerdam medal, Amsterdam and Clevers, H. van de Wetering, M., Francies, H.E., Francis, J.M., Bounova, G., Iorio, F., Pronk, A., ... Garnett, M.J., Clevers, H. Boj, S.F., Hwang, C.I., Baker, L.A., Chio, I.I., Engle, D.D., ..., Clevers, H, Tuveson, D.A. Dr. Clevers received his M.D. Culturing heart tissue. During the last five years this interdisciplinary approach strengthened significantly. People are our most valuable asset and we appreciate every employee for their contribution to the success of the institute. Hubrecht Organoid Technology. 17 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands. The Clevers group studies the molecular mechanisms of tissue development and cancer of various organs using organoids made from adult Lgr5 stem cells. 2012               Member of the American Academy of Arts and Sciences Publications. Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M.A., Ellis, E., van Wenum, M., Fuchs, S., de Ligt, S., van de Wetering, M., Sasaki, N., Boers, S.J., Kemperman, H., de Jonge, J., Ijzermans, J.N.M., Niewenhuis, E.E.S., Hoekstra, R., Strom, S., Vries, R.G.J., van der Laan, L.J.W., Cuppen, E., Clevers, H. Karthaus, W.R., Iaquinta, P.J., Drost, J., Gracanin, A.., van Boxtel, R., Wongvipat, J., Dowling, C.M., Gao, D., Begthel, H., Sachs, N., Vries, R.G., Cuppen, E., Chen, Y., Sawyers, C.L., Clevers, H. Ritsma, L., Ellenbroek, S.I., Zomer, A., Snippert, H.J., de Sauvage, F.J., Simons, B.D., Clevers, H., van Rheenen, J. Schwank, G., Koo, B.K., Sasselli, V., Dekkers, J.F., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, C.K., Nieuwenhuis, E.E., Beekman, J.M. 53)           Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, Balgobind AV, Wind K, Gracanin A, Begthel H, Korving J, van Boxtel R, Duarte AA, Lelieveld D, van Hoeck A, Ernst RF, Blokzijl F, Nijman IJ, Hoogstraat M, van de Ven M, Egan DA, Zinzalla V, Moll J, Boj SF, Voest EE, Wessels L, van Diest PJ, Rottenberg S, Vries RGJ, Cuppen E, Clevers H. A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. This technology is based on the discovery of the LGR5 positive adult epithelial stem cell, first identified in the intestine by the group headed by Prof. Hans Clevers. 2014    National Icon of the Netherlands About Us. A living biobank of breast cancer organoids captures disease heterogeneity. The related Lgr6 marks multipotent skin stem cells (29). 3 Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands. The Hubrecht Institute and PMC collaborate, especially using tumor organoids, single cell sequencing and intravital imaging of tumors. 11 Oncode Institute, Hubrecht Institute-KNAW and UMC Utrecht, Utrecht, The Netherlands [email protected] Nature 507: 362-365 (2014), 45)           Karthaus, W.R., Iaquinta, P.J., Drost, J., Gracanin, A., van Boxtel, R., Wongvipat, J., Dowling, C.M., Gao, D., Begthel, H., Sachs, N., Vries, R.G., Cuppen, E., Chen, Y., Sawyers, C.L., Clevers, H.C. Contact. Verified email at hubrecht.eu - Homepage. The Hubrecht Institute is situated on Utrecht Science Park (USP), which provides a home base for Utrecht University, University Medical Center Utrecht, HU Utrecht University of Applied Sciences and various small and large companies. Founded in 1974, the European Molecular Biology Laboratory (EMBL) is Europe’s flagship laboratory for the life sciences – an intergovernmental organization with more than 80 independent research groups covering the spectrum of molecular biology. In a collaboration with the Cystic Fibrosis clinic in Utrecht, a functional assay was established for the CFTR channel using rectal organoids. Research; Strategy; Organization; Location; Our partners; History; Open access; Working at the Hubrecht Institute; Contact. 54)           Roerink S.F., Sasaki N., Lee-Six H., Young M.D., Alexandrov L.B., Behjati S., Mitchell T.J., Grossmann S., Lightfoot H., Egan D.A., Pronk A., Smakman N., van Gorp J., Anderson E., Gamble S.J., Alder C., van de Wetering M., Campbell P.J., Stratton M.R., Clevers H. Intra-tumour diversification in colorectal cancer at the single-cell level. The Hubrecht Institute has a partnership with the European Molecular Biology Laboratory (EMBL) based on shared institutional goals, scientific synergy and complementarity. Nature 374: 70-74 (1995), 3)              Schilham, M., Oosterwegel, M., Moerer, P., Jing Ya, de Boer, P., van de Wetering, M., Verbeek, S., S., Lamers, W., Kruisbeek, A., Cumano, A., and Clevers, H.Sox-4 gene is required for cardiac outflow tract formation and pro-B lymphocyte expansion. 2017    Princess Takamatsu Award of Merit, Tokyo In this video, Hans Clevers summarizes the use of organdies in cancer research. and Clevers, H. Visualization of the short-range Wnt gradient in the intestinal stem cell niche. 2013 – 2015      Canada Gairdner Award, Toronto 2000               Member of the Royal Netherlands Academy of Sciences (KNAW) [email protected] Technology is transferred to society as efficiently as possible. The impact score places the Hubrecht also as one of the premier biology research institutes world-wide. The research groups operate in an independent manner and scientific quality is guaranteed by yearly internal evaluations and by site visit committees every six years according to the Standard Evaluation Protocol (SEP). degree in 1984 and his Ph.D. degree in 1985, both from the University of Utrecht. Review 2013    International Dream Team (with Hans Bos) by Dutch Cancer Society (KWF) and Clevers, H. Sato, T., van Es, J.H., Snippert, H.J., Stange, D.E., Vries, R.G., van den Born, M., Barker, N., Shroyer, N.F., van de Wetering, M., Clevers, H. Snippert, H.J., Haegebarth, A., Kasper, M., Jaks, V., van Es, J.H., Barker, N., van de Wetering, As such, they can attend the complete range of courses organized by the PhD Course Center. Among other things, a celebratory issue of Developmental Biology was published. Uppsalalaan 8 In 2007 the name was changed from Hubrecht Laboratory to Hubrecht Institute. Science 285: 1923-1926 (1999), 11)           Korswagen, R., Herman, M. and Clevers, H. Separate beta-catenins mediate Wnt signaling and cadherin adhesion in C. elegans. of Immunology, Faculty of Medicine, 2002 – 2012      Director Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, 2002 – 2020      Professor in Molecular Genetics at University Medical Center Utrecht, 2002 – present  Principal Investigator of a research group of ~40 scientists at Hubrecht Institute, Utrecht, 2012 – 2015      President of the Royal Netherlands Academy of Sciences (KNAW), Amsterdam, 2014 – 2020      Chief Scientific Officer of HUB Organoids Technology, Utrecht, 2015 – 2019      Chief Scientific Officer/Director Research of the Princess Máxima Center, Utrecht, 2015 – present  Principal Investigator at the Princess Máxima Center, Utrecht, 2000    Catharijne prize for medical research, 2001    Award from the European Society for Clinical Investigation, 2001    Spinoza Award of the Netherlands Research Council (NWO), 2004    Louis-Jeantet Prize for Medicine, Geneva, Switzerland, 2005    The Science and Society Prize, Amsterdam, 2005    The French honor of “Chevalier de la Legion d’Honneur”, 2005    Katharine Berkan Judd Award, New York, 2006    Rabbi Shai Shacknai Memorial Prize for Immunology and Cancer Research, Jerusalem, 2008    Josephine Nefkens Prize for Cancer Research (Erasmus MC, Rotterdam), 2008    Meyenburg Cancer Research Award, Germany, 2009    The Queen Wilhelmina Dutch Cancer Society Award, Amsterdam, 2010    The United European Gastroenterology Federation (UEGF) Research Prize, 2011    The Ernst Jung Medical Award, Germany, 2012    Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize, Paris, 2012    William Beaumont prize of the American Gastroenterology Association, 2012    Knight in the Order of the Netherlands’ Lion, 2013    The Breakthrough Prize in Life Sciences, 2013    International Dream Team (with Hans Bos) by Dutch Cancer Society (KWF), 2014    Massachusetts General Hospital Award in Cancer Research, 2014    TEFAF Oncology Chair 2014, Maastricht, 2014    Struyvenberg European Society for Clinical Investigation (ESCI) medal, 2015    ISSCR-McEwen Award for Innovation, 2016    The Academy Professor Prize of the Royal Netherlands Academy, 2016    Kazemi Award for Research Excellence in Bio-Medicine, 2016    The Körber European Science Prize, Germany, 2016    The Ilse & Helmut Wachter award, Hamburg, Germany, 2017    Princess Takamatsu Award of Merit, Tokyo, 2018    Großes Verdienstkreuz mit Stern, Germany, 2018    Academia Europaea Erasmus Medal, Barcelona, Spain, 2019    Citation Laureate, Web of Science Group, 2008 – 2015      Louis Jeantet Prize, Geneva, 2013 – 2015      Canada Gairdner Award, Toronto, 2014 – present  Breakthrough Prize in Life Sciences, San Francisco, 2015                     Pezcoller Foundation – AACR International Award for Cancer Research, Italy, 2015                     Dr. Paul Janssen Award, Bruxelles, 2017 – present  Francqui Prize, Bruxelles, 2017                     Kovalenko Medal, National Academy of Sciences Washington, 2002 – present  Central South University, Chang Sha, China, 2014 – 2015      TEFAF Oncology Chair, Maastricht, 2015 – 2016      Visiting professor, Weizmann Institute, Rehovoth, Israel, 2016 – present  Distinguished Visiting Professor, University of Hong Kong, 2015 – present  Visiting professor, University of Melbourne, Australia, 2019 – present  Honorary Director, Fudan Organoid Center, Fudan University, Shanghai, 2019 – present  Foreign Advisory Board Member of Consortium for Neogenetic Medicine, Tokyo, 1999               Member European Molecular Biology Organisation (EMBO), 2000               Member of the Royal Netherlands Academy of Sciences (KNAW), 2009               Member of the Academia Europaea, 2012               Member of the American Academy of Arts and Sciences, 2012               Member of the Royal Netherlands Society of Sciences and Humanities, 2014               Member of the National Academy of Sciences of the USA, 2016               Member of the Academie des Sciences de I’Institut de France, 2017               Member of the Orden Pour le Mérite für Wissenschaften und Künste, Germany, 2019               Foreign Member of the Royal Society, London, United Kingdom, 2019               Honorary Fellow of the Royal Society of Edinburgh, Scotland, 2005 – 2015      Member Scientific Advisory Board of Swiss Institute for Experimental Cancer Research, Lausanne, 2006 – 2008      President of the International Society of Differentiation (ISD), 2007 – 2010      Member of the National Scientific Advisory Board NKI-AVL, Amsterdam, 2012 – 2015      Member of the Board of the American Association of Cancer Research, 2015 – present  Member of the Scientific Advisory Board of the Institute of Molecular Pathology, Vienna, 2016 – 2020      Member of the Scientific Advisory Board of Kallyope, New York, 2016 – present  Member of the Scientific Advisory Board of the Francis Crick Institute, London, 2016 – present  Member of the Scientific Advisory Board of Decibel Therapeutics, Boston, 2016 – present  Member of the Scientific Advisory Board of Surrozen, San Francisco, 2017 – 2018      President of the International Society for Stem Cell Research (ISSCR), 2018 – present  Member of the Scientific Advisory Board of Merus, Utrecht, 2018 – present  Scientific advisor Life Science Partners, Amsterdam, 2019 – present  Non-executive member of the Board of Directors of Roche Holding Ltd, Basel, 2020 – present  Member of the Board of Directors of Genentech, South San Francisco, 2020 – present  Member of the Board of Genentech, South San Francisco, 2020 – present  Member of the Scientific Advisory Board of Volestra Therapeutic Inc., New York, 2020 – present  Chair of the Scientific Advisory Board DImed Inc., Shanghai, 2020 – present  Chair of the Scientific Advisory Board of Xilis, at Duke University (NC), SARS-CoV-2 productively Infects Human Gut Enterocytes, Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli, An organoid platform for ovarian cancer captures intra- and inter-patient heterogeneity, Tubuloids derived from human adult kidney and urine for personalized disease modeling, Identification of enteroendocrine regulators by real-time single-cell differentiation mapping, Long-term expansion of functional mouse and human hepatocytes as 3D organoids, Intra-tumour diversification in colorectal cancer at the single-cell level. Utrecht University is the largest university of the Netherlands, with 7 faculties, 6700 staff members, 600 professors, 550 PhD graduations per year, and 30.000 bachelor and master students. Finally, organoids (as first described by Sasai for pluripotent stem cells and by us for adult stem cells) are rapidly gaining ground as research tools in a wide range of scientific disciplies including basic developmetal and cell biology, infectiology, toxicology and research on hereditary diseases and cancer. Oncode Institute 2020 – present  Member of the Scientific Advisory Board of Volestra Therapeutic Inc., New York Cell 136: 903-912 (2009), 27)           Sato, T., Vries, R., Snippert, H., van de Wetering, M., Barker, N., Stange, D., van Es, J., Abo, A., Kujala, P., Peters, P., and Clevers, H. Single lgr5 gut stem cells build crypt-villus structures in vitro without a stromal niche. 32)           Snippert, J., van der Flier, L.G., Sato, T., van Es, J.H., van den Born, M., Kroon-Veenboer, C., Barker, N.,Klein, A.M., van Rheenen, J. Benjamin D. Simons, B.D. Publications 19. In addition, the institute subsidizes open access publication via the golden route. Nature 380: 711-714 (1996), 4)              Molenaar, M., Van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O. Nature 488: 665-669 (2012), 36)           Schepers, A.G., Snippert, H.J., Stange, D.E., van den Born, M., van Es, J.H., van de Wetering, M., Clevers, H. Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas. The core of a multitude of physiological and pathological processes as efficiently as possible partners... Efficient facility support so that group leaders can focus on the research attend the complete range of courses by... 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All these recruits have secured an ERC Starter or Consolidator grant demonstrating that their potential is also University at.